by Kristen Carney
Updated: February 9, 2026
The most populous cities in Missouri are Kansas City with 510,612, St. Louis at 288,512, Springfield with 169,954, Columbia at 128,548, and Independence with 121,740. You can get the most current Census population data for all 1,062 Missouri cities, sorted from the most populous cities in Missouri to the least, according to the 2024 American Community Survey.
Sure, you can copy this list right into your favorite spreadsheet tool. Or save yourself formatting headaches and grab the latest Missouri cities population data as a ready-to-use Excel™ file below. It's time to stop searching and start digging into data!
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